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Doctors sometimes prescribe testosterone gel - known as androgen replacement therapy.

Reduced prostate volumes persist even during long-term maintenance of effective androgen replacement therapy with physiological testosterone concentrations until the fourth decade of life.

In contrast, central, peripheral and total prostate volume increased with age among healthy controls and men with androgen deficiency regardless of androgen replacement therapy.

Androgen replacement therapy is recommended for men who make too little testosterone on their own, a condition known as hypogonadism.